DEVELOPING NOVEL NANOBIOSENSORS TO DETECT BIOMOLECULAR INTERACTIONS
Detecting biomolecular interactions where biomolecules (e.g. proteins, peptides, small molecules, and oligonucleotides etc.) bind to their targets in specific signaling cascades is crucial to the advancement of cancer and stem cell biology. To this end, we have developed hybrid nanomaterial-based biosensing systems; and utilized the developed nanomaterial-based biosensors to detect bioanalytes from cancer and stem cells in a highly sensitive and selective way. In particular, we have integrated graphene nanomaterials to field-effect transistor (FET)-based biosensors, which have recently attracted much interest owing to several unique advantages over nanomaterial-based biosensors, including higher 2-D electrical conductivity, excellent mechanical flexibility, larger surface area, and high chemical and thermal stability.
Key Reference Papers from KBLEE group:
1. Myung, S.; Solanki, A.; Kim, C.; Park, J.; Kim, K. S.; Lee, K.-B.†, ” Graphene-encapsulated Nanoparticle-based Biosensor for the Selective Detection of Cancer Biomarkers”, Advanced Materials, 2011, 23, 2221–2225.
2. Reyes, P. I.; Ku, C.-J.; Duan, Z.; Lu, Y.†; Solanki A.; Lee, K.-B.†, “ZnO Thin Film Transistor Immunosensor with High Sensitivity and Selectivity”, Applied Physics Letters, 2011, 98, 173702.
3. Myung, S.; Kim, C.; Yin, P. T.; Park, J.S.; Solanki, A.; Reyes, P. I.; Yicheng, L.; Kim, K. S.; Lee, K.-B.†, “Label-free Polypeptide-based Enzyme Detection Using a Graphene-nanoparticle Hybrid Sensor”, Advanced Materials, In Press